1.
Bioorg Med Chem
; 7(3): 517-27, 1999 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10220037
RESUMO
The synthesis, physicochemical properties, and toxicological implications of a novel series of N-2-(azol-1(2)-yl)ethyliminodiacetic acids, useful as contrast agents for magnetic resonance imaging are reported. Compounds were prepared by alkylation of methyl iminodiacetate with N-2-bromoethylazoles and subsequent hydrolysis. Stability constants of the corresponding Gd(III) complexes and T1 and T2 relaxivities were determined and interpreted in terms of optimized geometries obtained by semiempirical PM3 calculations. Compounds show increased T2 relaxivity and decreased toxicity in vitro as compared to EDTA-Gd(III) complexes.
Assuntos
Acetatos/química , Quelantes/química , Meios de Contraste/química , Gadolínio/química , Acetatos/síntese química , Acetatos/toxicidade , Cálcio/química , Carcinoma Hepatocelular/enzimologia , Carcinoma Hepatocelular/patologia , Quelantes/síntese química , Quelantes/toxicidade , L-Lactato Desidrogenase/metabolismo , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Termodinâmica , Células Tumorais Cultivadas
2.
Br J Urol
; 79(1): 130, 1997 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9043514